The endometrium has the ability to experience cyclical changes in response to different hormonal stimuli that occur during the menstrual cycle. These changes are known as the endometrial cycle. The endometrial cycle is divided into three phases: the proliferative phase, the secretory phase and the menstrual phase.

1- The proliferative phase: starting from the end of the menstrual period to ovulation, ie, between the 4th to 14th day of the cycle. During this phase, egg development occurs and is mainly mediated by estrogen. The endometrium reaches a thickness of 1-3 mm. During this phase the endometrial lining grows due to development of the endometrial glands, the stroma and the vascular component.

2- The secretory phase: also known as the luteal phase begins at the time of ovulation up to menstruation, ie between the 14th to 28th days of the cycle. It is this phase the corpus luteum produces high levels of estrogen and progesterone. The endometrium reaches 5-6 mm thickness. The glands have some morphological changes and secretory activity becoming more tortuous and dilated. The endometrial spiral arteries are also developed.

3- The menstrual phase: in the absence of pregnancy, a sudden decline of estrogen and progesterone production by the corpus luteum produces endometrial ischemia due to vasoconstriction of the spiral arteries between 1 to 24 hours before menstruation. After the period of vasoconstriction there is return of blood flow to the superficial layers of the endometrium, resulting in detachment only of the basal layer. During this phase, uterine contractions occur to facilitate the expulsion of endometrial tissue.

Hysteroscopy Newsletter

1 comment on “Endometrial Cycle


    Hi I think the endometrial thickness range during the three phases can be more


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: